黄宝玉，男，理学博士，鲁东大学副教授 

研究方向：贝类天然免疫。近几年主持国家自然科学基金青年项目、中国博士后科学基金面上项目、山东省博士后创新项目资助等国家及省级课题。围绕贝类天然免疫通路及关键基因进行深入研究。在Aquaculture，Frontiers in Immunology，International Journal of Biological Macromolecules，Scientific Reports，Fish & Shellfish Immunology，Developmental and Comparative Immunology，Marine Biotechnology等期刊发表SCI论文40余篇，其中以第一或通讯作者发表20篇。获授权国家发明专利一项。

教育经历：

2006-09 ~ 2010-07 山东大学 生物技术专业 理学学士；

2010-09 ~ 2015-07 中国科学院大学（中国科学院海洋研究所） 海洋生物专业 理学博士。

工作经历：

2015-08 ~ 2018-07  中国科学院海洋研究所 博士后

2018-08 ~ 2019-07  中国科学院海洋研究所 助理研究员

2019-08至今  鲁东大学 副教授

主持完成的科研项目

1. 国家自然科学基金青年项目：长牡蛎干扰素调节因子免疫功能及作用机制研究；

2. 中国博士后科学基金面上资助：长牡蛎IRF抗病毒转录调控机制的研究；

3. 山东省博士后创新项目资助：长牡蛎Rel/NF-κB的免疫功能，调控蛋白及其可变剪切的研究。

发表论文（以第一或通讯作者发表SCI论文20篇。*通讯作者）：

1. Liu, Wenjuan, Ma, Jilv, Chen, Jiwen, Huang, Baoyu*, Liu, Fengchen, Li, Lingling, Fan, Nini, Li, Fangshu, Zheng, Yanxin, Zhang, Xuekai, Wang*, Xiaona, Wang, Xiaomei, Wei, Lei, Liu, Yaqiong, Zhang, Meiwei, Han, Yijing, Wang, Xiaotong*. A novel TBK1/IKKϵ is involved in immune response and interacts with MyD88 and MAVS in the scallop Chlamys farreri. Frontiers in Immunology. 2023, 13, 1091419. （IF: 8.786）

2. Li Fangshu¹, Liu Wenjuan¹, Chen Jiwen, Huang Baoyu*, Zheng Yanxin, Ma Jilv, Cai Shuai, Li Lingling, Liu Fengchen, Wang Xiaona, Wei Lei, Liu Yaqiong, Zhang Meiwei, Han Yijing, Zhang Xuekai, Wang Xiaotong*, CfIRF8-like interacts with the TBK1/IKKε family protein and regulates host antiviral innate immunity, Fish & Shellfish Immunology, 2023, 132: 108497. （IF: 4.622）

3. Li Lingling¹, Liu Wenjuan¹, Fan Nini, Li Fangshu, Huang Baoyu*, Liu Qian, Wang Xiaomei, Zheng Yanxin, Sang Xiuxiu, Dong Juan, Wang Xiaona, Wei Lei, Liu Yaqiong, Zhang Meiwei, Ma Jilv, Chen Jiwen, Qi Yitao, Wang Xiaotong*, Scallop IKK1 responds to bacterial and virus-related pathogen stimulation and interacts with MyD88 adaptor of Toll-like receptor pathway signaling. Frontiers in Immunology. 2022; 13: 869845.（IF: 8.786）

4. Liu, Wenjuan, Li, Fangshu, Ma, Jilv, Chen, Jiwen, Huang, Baoyu*, Li, Lingling, Fan, Nini, Wang, Xiaomei, Zheng, Yanxin, Wang, Xiaona, Wei, Lei, Liu, Yaqiong, Zhang, Meiwei, Liu, Fengchen, Qi, Yitao, Wang, Xiaotong*. Scallop interferon regulatory factor 1 interacts with myeloid differentiation primary response protein 88 and is crucial for antiviral innate immunity. International Journal of Biological Macromolecules. 2022, 222, 1250-1263. （IF: 8.025）

5. Li Lingling¹, Liu Wenjuan¹, Li Fangshu, Huang Baoyu*, Liu Qian, Wang Xiaona, Sang Xiuxiu, Dong Juan, Ma Jilv, Chen Jiwen, Wei Lei, Liu Yaqiong, Zhang Meiwei, Han Yijing, Wang Xiaotong*. Scallop NEMO interacts with IKK1 and regulates host innate immunity against PAMPs. Aquaculture. 2022; 553: 738099. （IF: 5.135）

6. Huang Baoyu¹, Wu Yuzheng¹, Ma Jilv, Yang Baoju*, Sang Xiuxiu, Chen Jiwen, Liu Wenjuan, Li Fangshu, Li Lingling, Wang Xiaona, Dong Juan, Wang Xiaotong*. The first identified invertebrate LGP2-like homolog gene in the Pacific oyster Crassostrea gigas. Fish & Shellfish Immunology. 2022; 128, 238-245. （IF: 4.622）

7. Sang Xiuxiu, Liu Wenjuan, Li Fangshu, Huang Baoyu, Li Lingling, Wang Xiaona, Dong Juan, Ma Jilv, Chen Jiwen, Wang Xiaotong*. Scallop RIG-I-like receptor 1 responses to polyinosinic:polycytidylic acid challenge and its interactions with the mitochondrial antiviral signaling protein. Fish & Shellfish Immunology. 2022; 124: 490-496. （IF: 4.622）

8. Liu Qian¹, Li Fangshu¹, Liu Wenjuan, Huang Baoyu*, Li Lingling, Wang Xiaona, Sang Xiuxiu, Dong Juan, Ma Jilv, Chen Jiwen, Wei Lei, Liu Yaqiong, Zhang Meiwei, Han Yijing, Wang Xiaotong*. Transcriptional expression analysis reveals multiple effects of nonylphenol exposure on scallop immune system. Fish & Shellfish Immunology. 2022; 123: 290-297.（IF: 4.622）

9. Huang Baoyu, Dong Juan, Sang Xiuxiu, Li Lingling, Li Fangshu, Ma Jilv, Wang Xiaona, Wang Xiaotong*, Liu Yongsheng*. A review on marine mollusk NF-κB/Rel studies in immunity and the characterization of a Chlamys farreri Rel gene. Aquaculture. 2021; 544: 737046. （IF: 4.242）

10. Huang Baoyu*, Sang Xiuxiu, Dong Juan, Li Lingling, Wang Xiaona, Yang Baoju, Wei Lei, Liu Yaqiong, Zhang Meiwei, Wang Xiaotong*, Oyster TBK1/IKKε responds to bacterial and viral challenges and participates in the innate immune signaling. Aquaculture. 2021; 534: 736276. （IF: 4.242）

11. Sang Xiuxiu¹, Dong Juan¹, Chen Fengmei, Wei Lei, Liu Yaqiong, Zhang Meiwei, Huang Baoyu*, Wang Xiaoton*, Molecular cloning and immune function study of an oyster IκB gene in the NF-κB signaling pathway. Aquaculture. 2020; 525: 735322.（IF: 3.225）

12. Dong Juan¹, Sang Xiuxiu¹, Song Hongce, Zhan Rui, Wei Lei, Liu Yaqiong, Zhang Meiwei, Huang Baoyu*, Wang Xiaotong*, Molecular characterization and functional analysis of a Rel gene in the Pacific oyster. Fish & Shellfish Immunology. 2020; 101: 9-18.

13. Huang Baoyu¹, Tang Xueying¹, Zha Fish & Shellfish Immunology ng Linlin, Li Li*, Wang Wei, Liu Mingkun, Zhang Guofan*. IKKε-like plays an important role in the innate immune signaling of the Pacific oyster (Crassostrea gigas). Fish & Shellfish Immunology. 2019; 93: 551-558. （IF: 3.298）

14. Huang Baoyu, Zhang Linlin, Xu Fei, Tang Xueying, Li Li*, Wang Wei, Liu Mingkun, Zhang Guofan*. Oyster versatile IKKα/βs are involved in Toll-like receptor and RIG-I-like receptor signaling for innate immune response. Frontiers in Immunology. 2019; 10:1826. （IF：4.716）

15. Huang Baoyu¹, Zhang Linlin¹, Du Yishuai, Xu Fei, Li Li*, Zhang Guofan*. Characterization of the Mollusc RIG-I/MAVS Pathway Reveals an Archaic Antiviral Signalling Framework in Invertebrates. Scientific Reports. 2017; 7: 8217. （IF: 4.122）

16. Huang Baoyu¹, Meng Jie¹, Yang Mei, Xu Fei, Li Xinzheng*, Li Li*, Zhang Guofan, Characterization of the IRF2 proteins isolated from the deep-sea mussel Bathymodiolus platifrons and the shallow-water mussel Modiolus modiolus. Developmental and Comparative Immunology. 2017; 71: 82-87. （IF: 2.913）

17. Huang Baoyu, Zhang Linlin, Du Yishuai, Li Li*, Tang Xueying, Zhang Guofan*. Molecular characterization and functional analysis of tumor necrosis factor receptor-associated factor 2 in the Pacific oyster. Fish & Shellfish Immunology. 2016; 48: 12-19. （IF: 3.148）

18. Huang Baoyu¹, Zhang Linlin¹, Tang Xueying, Zhang Guofan, Li Li*. Genome-Wide Analysis of Alternative Splicing Provides Insights into Stress Adaptation of the Pacific Oyster. Marine Biotechnology. 2016; 18: 598-609. （IF: 2.748）

19. Huang Baoyu, Zhang Linlin, Li Li, Tang Xueying, Zhang Guofan. Highly diverse fibrinogen-related proteins in the Pacific oyster Crassostrea gigas. Fish & Shellfish Immunology. 2015; 43: 485-490.（IF: 3.025）

20. Huang Baoyu, Zhang Linlin, Du Yishuai, Li Li*, Qu Tao, Meng Jie, Zhang, Guofan*. Alternative splicing and immune response of Crassostrea gigas tumor necrosis factor receptor-associated factor 3. Molecular Biology Reports. 2014; 41: 6481-6491.（IF: 1.889）

申请专利：

长牡蛎Poly(I:C)应激实验荧光定量的内参基因及其引物和应用，专利号：ZL201410257711.7 (第一位，已授权)。

联系方式：

邮箱：byhuang@ldu.edu.cn